Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliar...

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Bibliographic Details
Main Authors: Linh T. Vuong, Carlo Iomini, Sophie Balmer, Davide Esposito, Stuart A. Aaronson, Marek Mlodzik
Format: Article
Language:English
Published: Nature Publishing Group 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07605-z
Description
Summary:IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.
ISSN:2041-1723

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