PATHOLOGICAL ANATOMY OF INFECTION CAUSED BY SARS-COV-2

• Main Authors: E. A. Kogan, Yu. S. Berezovsky, D. D. Protsenko, T. R. Bagdasaryan, E. M. Gretsov, S. A. Demura, G. A. Demyashkin, D. V. Kalinin, A. D. Kukleva, E. V. Kurilina, T. P. Nekrasova, N. B. Paramonova, A. B. Ponomarev, S. G. Radenska-Lopovok, L. A. Semyonova, A. S. Tertychny
• Format: Article
• Language: Russian
• Published: Eco-vector 2020-07-01
• Series: Судебная Медицина
• Subjects: covid-19 infection; etiology; pathogenesis; pathological anatomy
• Online Access: https://for-medex.ru/jour/article/viewFile/308/288

Autopsy data from 80 patients who died of the COVID-19 infection were analysed. Using macro- and microscopic studies, specific features of pathological processes in various organs were identified. The obtained experimental data, along with information from literature sources, allowed conclusions to be drawn about the mechanisms of damaging internal organs and body systems, as well as assumptions to be made about individual links in the pathogenesis of COVID-19. The thanatogenesis of the disease and the main causes of death are discussed, including acute cardiopulmonary failure, acute renal failure, pulmonary thromboembolism, shock involving multiple organ failure and sepsis. The critical importance of autopsy is emphasized, which provides valuable information on the morphological substrate for this infection closely associated with possible clinical manifestations.