Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure

Abstract Background High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and long-term (10 years) mortality in patients with or without pre-existing...

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Main Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ilan Goldenberg, Robert Klempfner, Yoel Toledano, Yitschak Biton, Enrique Z. Fisman, Alexander Tenenbaum, Gregory Golovchiner, Ehud Kadmon, Alexander Omelchenko, Tuvia Ben Gal, Alon Barsheshet
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cardiovascular Diabetology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12933-017-0582-y
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spelling doaj-7890701196764f9a8b47291a4faad4842020-11-24T21:10:43ZengBMCCardiovascular Diabetology1475-28402017-08-011611910.1186/s12933-017-0582-yAdmission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failureOsnat Itzhaki Ben Zadok0Ran Kornowski1Ilan Goldenberg2Robert Klempfner3Yoel Toledano4Yitschak Biton5Enrique Z. Fisman6Alexander Tenenbaum7Gregory Golovchiner8Ehud Kadmon9Alexander Omelchenko10Tuvia Ben Gal11Alon Barsheshet12Department of Cardiology, Rabin Medical CenterDepartment of Cardiology, Rabin Medical Center“Leviev” Heart Center, Sheba Medical Center“Leviev” Heart Center, Sheba Medical CenterDivision of Maternal–Fetal Medicine, Helen Schneider Hospital for Women, Rabin Medical Center“Leviev” Heart Center, Sheba Medical Center“Leviev” Heart Center, Sheba Medical Center“Leviev” Heart Center, Sheba Medical CenterDepartment of Cardiology, Rabin Medical CenterDepartment of Cardiology, Rabin Medical CenterDepartment of Cardiology, Rabin Medical CenterDepartment of Cardiology, Rabin Medical CenterDepartment of Cardiology, Rabin Medical CenterAbstract Background High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and long-term (10 years) mortality in patients with or without pre-existing diabetes mellitus (DM) admitted with HF. Methods We analyzed data on 1811 patients with DM and 2182 patients without pre-existing DM who were hospitalized with HF during a prospective national survey. The relationship between ABG and 10-year mortality was assessed using the Cox proportional hazard model adjusting for multiple variables. ABG was analyzed both as a categorical (<110, 110–140, 140–200, and >200 mg/dL) and as a continuous variable. Results At 10 years of follow-up the cumulative probability of mortality was 85 and 78% among patients with DM and patients with no pre-existing DM (p < 0.001), respectively. Among patients with no pre-existing DM, glucose levels of 110–140, 140–200 and ≥200 mg/dL were associated with 9% (p = 0.140), 16% (p = 0.031) and 53% (p < 0.001) increased mortality risk compared to ABG < 110 mg/dL. Each 18-mg/dL (1-mmol/L) increase in glucose level was associated with a 5% increased risk of mortality (p < 0.001) among patients with no-pre-existing DM. In contrast, among patients with DM, only those with glucose levels >200 mg/dL had an increased mortality risk (>200 mg/dL versus <110 mg/dL; HR = 1.20, p = 0.032). Conclusion Among hospitalized HF patients with no pre-existing DM there is a linear relationship between ABG level and long-term mortality, whereas among patients with DM only ABG level >200 mg/dL is associated with increased mortality risk.http://link.springer.com/article/10.1186/s12933-017-0582-yHeart failureDiabetes mellitusPrognosisAdmission blood glucose
collection DOAJ
language English
format Article
sources DOAJ
author Osnat Itzhaki Ben Zadok
Ran Kornowski
Ilan Goldenberg
Robert Klempfner
Yoel Toledano
Yitschak Biton
Enrique Z. Fisman
Alexander Tenenbaum
Gregory Golovchiner
Ehud Kadmon
Alexander Omelchenko
Tuvia Ben Gal
Alon Barsheshet
spellingShingle Osnat Itzhaki Ben Zadok
Ran Kornowski
Ilan Goldenberg
Robert Klempfner
Yoel Toledano
Yitschak Biton
Enrique Z. Fisman
Alexander Tenenbaum
Gregory Golovchiner
Ehud Kadmon
Alexander Omelchenko
Tuvia Ben Gal
Alon Barsheshet
Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
Cardiovascular Diabetology
Heart failure
Diabetes mellitus
Prognosis
Admission blood glucose
author_facet Osnat Itzhaki Ben Zadok
Ran Kornowski
Ilan Goldenberg
Robert Klempfner
Yoel Toledano
Yitschak Biton
Enrique Z. Fisman
Alexander Tenenbaum
Gregory Golovchiner
Ehud Kadmon
Alexander Omelchenko
Tuvia Ben Gal
Alon Barsheshet
author_sort Osnat Itzhaki Ben Zadok
title Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
title_short Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
title_full Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
title_fullStr Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
title_full_unstemmed Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
title_sort admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
publisher BMC
series Cardiovascular Diabetology
issn 1475-2840
publishDate 2017-08-01
description Abstract Background High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and long-term (10 years) mortality in patients with or without pre-existing diabetes mellitus (DM) admitted with HF. Methods We analyzed data on 1811 patients with DM and 2182 patients without pre-existing DM who were hospitalized with HF during a prospective national survey. The relationship between ABG and 10-year mortality was assessed using the Cox proportional hazard model adjusting for multiple variables. ABG was analyzed both as a categorical (<110, 110–140, 140–200, and >200 mg/dL) and as a continuous variable. Results At 10 years of follow-up the cumulative probability of mortality was 85 and 78% among patients with DM and patients with no pre-existing DM (p < 0.001), respectively. Among patients with no pre-existing DM, glucose levels of 110–140, 140–200 and ≥200 mg/dL were associated with 9% (p = 0.140), 16% (p = 0.031) and 53% (p < 0.001) increased mortality risk compared to ABG < 110 mg/dL. Each 18-mg/dL (1-mmol/L) increase in glucose level was associated with a 5% increased risk of mortality (p < 0.001) among patients with no-pre-existing DM. In contrast, among patients with DM, only those with glucose levels >200 mg/dL had an increased mortality risk (>200 mg/dL versus <110 mg/dL; HR = 1.20, p = 0.032). Conclusion Among hospitalized HF patients with no pre-existing DM there is a linear relationship between ABG level and long-term mortality, whereas among patients with DM only ABG level >200 mg/dL is associated with increased mortality risk.
topic Heart failure
Diabetes mellitus
Prognosis
Admission blood glucose
url http://link.springer.com/article/10.1186/s12933-017-0582-y
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