Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.

Bibliographic Details
Main Authors:	Marco D. Carpenter, Qiwen Hu, Allison M. Bond, Sonia I. Lombroso, Kyle S. Czarnecki, Carissa J. Lim, Hongjun Song, Mathieu E. Wimmer, R. Christopher Pierce, Elizabeth A. Heller
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14331-y

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spelling	doaj-78819fd7dce048ceba481adca31e28682021-05-11T08:31:01ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-020-14331-yNr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genesMarco D. Carpenter0Qiwen Hu1Allison M. Bond2Sonia I. Lombroso3Kyle S. Czarnecki4Carissa J. Lim5Hongjun Song6Mathieu E. Wimmer7R. Christopher Pierce8Elizabeth A. Heller9Department of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaPenn Epigenetics Institute, Perelman School of Medicine, University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaPenn Epigenetics Institute, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychology and Program in Neuroscience, Temple UniversityCenter for Nurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of PennsylvaniaDepartment of Systems Pharmacology and Translational Therapeutics, University of PennsylvaniaThe regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.https://doi.org/10.1038/s41467-020-14331-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller
spellingShingle	Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes Nature Communications
author_facet	Marco D. Carpenter Qiwen Hu Allison M. Bond Sonia I. Lombroso Kyle S. Czarnecki Carissa J. Lim Hongjun Song Mathieu E. Wimmer R. Christopher Pierce Elizabeth A. Heller
author_sort	Marco D. Carpenter
title	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_short	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_full	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_fullStr	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_full_unstemmed	Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
title_sort	nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.
url	https://doi.org/10.1038/s41467-020-14331-y
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Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

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