Tim‐3 suppresses autoimmune hepatitis via the p38/MKP‐1 pathway in Th17 cells

Tim‐3 suppresses autoimmune hepatitis via the p38/MKP‐1 pathway in Th17 cells

T‐cell immunoglobulin‐ and mucin‐domain‐containing molecule‐3 (Tim‐3) mediates T‐cell suppression in various autoimmune diseases, such as chronic inflammatory liver disease. However, the regulatory effect of Tim‐3 on Th17 cells in autoimmune hepatitis (AIH) is incompletely understood. Here, we studi...

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Bibliographic Details
Main Authors: Hongwei Wu, Shiyue Tang, Mengya Zhou, Jiji Xue, Zhenjun Yu, Jiansheng Zhu
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:FEBS Open Bio
Subjects:
autoimmune hepatitis
Concanavalin A
MAPK
MKP‐1
Th17 cell
Tim‐3
Online Access:https://doi.org/10.1002/2211-5463.13148

Internet

https://doi.org/10.1002/2211-5463.13148

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