Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

Intracellular pH (pHi) dynamics is increasingly recognized as an important regulator of a range of normal and pathological cell behaviors. Notably, increased pHi is now acknowledged as a conserved characteristic of cancers and in cell models is confirmed to increase proliferation and migration as we...

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Bibliographic Details
Main Authors: Bree K Grillo-Hill, Changhoon Choi, Maite Jimenez-Vidal, Diane L Barber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/03270

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