Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication

Beneficial effects of cysteamine in Thy1-α-Syn mice and induced pluripotent stem cells with a SNCA gene triplication

A number of publications have reported that cysteamine has significant therapeutic effects on several aspects of Parkinson's disease (PD)-related pathology but none of these studies have evaluated its impact on pathological forms of α-Synuclein (α-Syn), one of the main hallmarks of PD. We there...

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Bibliographic Details
Main Authors: Alberto Siddu, Linda Suzanne David, Nadine Lauinger, Xiuqing Chen, Martine Saint-Pierre, Melanie Alpaugh, Thomas Durcan, Francesca Cicchetti
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neurobiology of Disease
Subjects:
Thy1-α-Syn mice
Cystamine
Neurodegenerative diseases
α-Syn
α-Syn phosphorylation
α-Syn fibrillation
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030317X

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