Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients

Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients

Human vascular pythiosis is a life-threatening condition caused by Pythium insidiosum. Patients with unresectable intra-abdominal artery involvement have not previously survived, despite being treated with antifungal agents and immunotherapy. We report two novel cases of intra-abdominal pythiosis in...

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Main Authors: Nuttapon Susaengrat, Pattama Torvorapanit, Rongpong Plongla, Nipat Chuleerarux, Kasama Manothummetha, Jarruprot Tuangsirisup, Navaporn Worasilchai, Ariya Chindamporn, Nitipong Permpalung
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971219303583
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spelling doaj-78539d31b67c468ab0f8fada404028a92020-11-24T21:50:06ZengElsevierInternational Journal of Infectious Diseases1201-97122019-11-01882730Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patientsNuttapon Susaengrat0Pattama Torvorapanit1Rongpong Plongla2Nipat Chuleerarux3Kasama Manothummetha4Jarruprot Tuangsirisup5Navaporn Worasilchai6Ariya Chindamporn7Nitipong Permpalung8Khonkaen Hospital, Khonkaen, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand; King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand; King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, ThailandKhonkaen Hospital, Khonkaen, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand; King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, ThailandFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Johns Hopkins University School of Medicine, Baltimore, MD, USA; Corresponding author at: Carnegie Building Room 340, 601 N Wolfe Street, Baltimore, MD 21287, USA.Human vascular pythiosis is a life-threatening condition caused by Pythium insidiosum. Patients with unresectable intra-abdominal artery involvement have not previously survived, despite being treated with antifungal agents and immunotherapy. We report two novel cases of intra-abdominal pythiosis in patients for whom surgery could not be performed, who were successfully treated with adjunctive antibacterial agents. Keywords: Vascular pythiosis, Azithromycin, Doxycycline, Clarithromycin, Voriconazolehttp://www.sciencedirect.com/science/article/pii/S1201971219303583
collection DOAJ
language English
format Article
sources DOAJ
author Nuttapon Susaengrat
Pattama Torvorapanit
Rongpong Plongla
Nipat Chuleerarux
Kasama Manothummetha
Jarruprot Tuangsirisup
Navaporn Worasilchai
Ariya Chindamporn
Nitipong Permpalung
spellingShingle Nuttapon Susaengrat
Pattama Torvorapanit
Rongpong Plongla
Nipat Chuleerarux
Kasama Manothummetha
Jarruprot Tuangsirisup
Navaporn Worasilchai
Ariya Chindamporn
Nitipong Permpalung
Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
International Journal of Infectious Diseases
author_facet Nuttapon Susaengrat
Pattama Torvorapanit
Rongpong Plongla
Nipat Chuleerarux
Kasama Manothummetha
Jarruprot Tuangsirisup
Navaporn Worasilchai
Ariya Chindamporn
Nitipong Permpalung
author_sort Nuttapon Susaengrat
title Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
title_short Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
title_full Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
title_fullStr Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
title_full_unstemmed Adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
title_sort adjunctive antibacterial agents as a salvage therapy in relapsed vascular pythiosis patients
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2019-11-01
description Human vascular pythiosis is a life-threatening condition caused by Pythium insidiosum. Patients with unresectable intra-abdominal artery involvement have not previously survived, despite being treated with antifungal agents and immunotherapy. We report two novel cases of intra-abdominal pythiosis in patients for whom surgery could not be performed, who were successfully treated with adjunctive antibacterial agents. Keywords: Vascular pythiosis, Azithromycin, Doxycycline, Clarithromycin, Voriconazole
url http://www.sciencedirect.com/science/article/pii/S1201971219303583
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