The CaMKII holoenzyme structure in activation-competent conformations

The CaMKII holoenzyme structure in activation-competent conformations

Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered link...

Full description

Bibliographic Details
Main Authors: Janette B. Myers, Vincent Zaegel, Steven J. Coultrap, Adam P. Miller, K. Ulrich Bayer, Steve L. Reichow
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15742
id doaj-7852f7f279904d55b15ee9e82bae8fc7
record_format Article
spelling doaj-7852f7f279904d55b15ee9e82bae8fc72021-05-11T07:35:03ZengNature Publishing GroupNature Communications2041-17232017-06-018111510.1038/ncomms15742The CaMKII holoenzyme structure in activation-competent conformationsJanette B. Myers0Vincent Zaegel1Steven J. Coultrap2Adam P. Miller3K. Ulrich Bayer4Steve L. Reichow5Department of Chemistry, Portland State UniversityDepartment of Pharmacology, University of ColoradoDepartment of Pharmacology, University of ColoradoDepartment of Chemistry, Portland State UniversityDepartment of Pharmacology, University of ColoradoDepartment of Chemistry, Portland State UniversityCa2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered linker domain in facilitating cooperative activation.https://doi.org/10.1038/ncomms15742
collection DOAJ
language English
format Article
sources DOAJ
author Janette B. Myers
Vincent Zaegel
Steven J. Coultrap
Adam P. Miller
K. Ulrich Bayer
Steve L. Reichow
spellingShingle Janette B. Myers
Vincent Zaegel
Steven J. Coultrap
Adam P. Miller
K. Ulrich Bayer
Steve L. Reichow
The CaMKII holoenzyme structure in activation-competent conformations
Nature Communications
author_facet Janette B. Myers
Vincent Zaegel
Steven J. Coultrap
Adam P. Miller
K. Ulrich Bayer
Steve L. Reichow
author_sort Janette B. Myers
title The CaMKII holoenzyme structure in activation-competent conformations
title_short The CaMKII holoenzyme structure in activation-competent conformations
title_full The CaMKII holoenzyme structure in activation-competent conformations
title_fullStr The CaMKII holoenzyme structure in activation-competent conformations
title_full_unstemmed The CaMKII holoenzyme structure in activation-competent conformations
title_sort camkii holoenzyme structure in activation-competent conformations
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Ca2+/calmodulin-dependent protein kinase II (CaMKII) forms a 12 subunit holoenzyme central to synaptic plasticity. Here the authors report a 3D structure of the CaMKII holoenzyme in an activation-competent state obtained by single particle EM, and suggest a role for the intrinsically disordered linker domain in facilitating cooperative activation.
url https://doi.org/10.1038/ncomms15742
work_keys_str_mv AT janettebmyers thecamkiiholoenzymestructureinactivationcompetentconformations
AT vincentzaegel thecamkiiholoenzymestructureinactivationcompetentconformations
AT stevenjcoultrap thecamkiiholoenzymestructureinactivationcompetentconformations
AT adampmiller thecamkiiholoenzymestructureinactivationcompetentconformations
AT kulrichbayer thecamkiiholoenzymestructureinactivationcompetentconformations
AT stevelreichow thecamkiiholoenzymestructureinactivationcompetentconformations
AT janettebmyers camkiiholoenzymestructureinactivationcompetentconformations
AT vincentzaegel camkiiholoenzymestructureinactivationcompetentconformations
AT stevenjcoultrap camkiiholoenzymestructureinactivationcompetentconformations
AT adampmiller camkiiholoenzymestructureinactivationcompetentconformations
AT kulrichbayer camkiiholoenzymestructureinactivationcompetentconformations
AT stevelreichow camkiiholoenzymestructureinactivationcompetentconformations
_version_ 1721452017958780928

Similar Items