Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

• Main Authors: Kebir Sied, Kuchelmeister Klaus, Niehusmann Pitt, Nelles Michael, Kim Young, Thanendrarajan Sharmilan, Schäfer Niklas, Stuplich Moritz, Mack Frederic, Scheffler Björn, Urbach Horst, Glas Martin, Herrlinger Ulrich
• Format: Article
• Language: English
• Published: BMC 2012-12-01
• Series: Experimental Hematology & Oncology
• Subjects: Intravascular lymphoma; Intravascular CNS lymphoma; High-dose methotrexate-based polychemotherapy; Angioendotheliomatosis; Angiotropic lymphoma
• Online Access: http://www.ehoonline.org/content/1/1/37

<p>Abstract</p> <p>Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.</p>