A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole

The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsi...

Full description

Bibliographic Details
Main Authors: K. Narasimha Sarma, M. C. S. Subha, K. Chowdoji Rao
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/979401
id doaj-7851932c96cc44d882347e4b4f2439ea
record_format Article
spelling doaj-7851932c96cc44d882347e4b4f2439ea2020-11-25T00:04:14ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017374575010.1155/2010/979401A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying IndoleK. Narasimha Sarma0M. C. S. Subha1K. Chowdoji Rao2Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, A.P., IndiaThe title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.http://dx.doi.org/10.1155/2010/979401
collection DOAJ
language English
format Article
sources DOAJ
author K. Narasimha Sarma
M. C. S. Subha
K. Chowdoji Rao
spellingShingle K. Narasimha Sarma
M. C. S. Subha
K. Chowdoji Rao
A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
E-Journal of Chemistry
author_facet K. Narasimha Sarma
M. C. S. Subha
K. Chowdoji Rao
author_sort K. Narasimha Sarma
title A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
title_short A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
title_full A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
title_fullStr A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
title_full_unstemmed A Facial Synthesis and Antimicrobial Activity of Some Pyrazole Derivatives Carrying Indole
title_sort facial synthesis and antimicrobial activity of some pyrazole derivatives carrying indole
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description The title compounds (7a-h) were prepared by esterification of indole-5-carboxylic acid (1) and subsequent treatment with hydrazine hydrate in methanol via the hydrazide (3). Finally hydrazide (3) condensed with different substituted aldol (6) in acetic acid / PTSA catalytic media produced (3,5-subsituted-4,5-dihydropyrazol-1-yl)(1H-indol-5-yl)methanone (7a-h) in good yields. All the newly synthesized compounds are by elemental analysis and spectral studies and evaluated for antimicrobial activities.
url http://dx.doi.org/10.1155/2010/979401
work_keys_str_mv AT knarasimhasarma afacialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
AT mcssubha afacialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
AT kchowdojirao afacialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
AT knarasimhasarma facialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
AT mcssubha facialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
AT kchowdojirao facialsynthesisandantimicrobialactivityofsomepyrazolederivativescarryingindole
_version_ 1725430434019409920

Similar Items