Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach

Structural Characterization of Full-Length Human Dehydrodolichyl Diphosphate Synthase Using an Integrative Computational and Experimental Approach

Dehydrodolichyl diphosphate synthase (DHDDS) is the catalytic subunit of the heteromeric human <i>cis</i>-prenyltransferase complex, synthesizing the glycosyl carrier precursor for N-linked protein glycosylation. Consistent with the important role of N-glycosylation in protein biogenesis...

Full description

Bibliographic Details
Main Authors: Michal Lisnyansky Bar-El, Su Youn Lee, Ah Young Ki, Noa Kapelushnik, Anat Loewenstein, Ka Young Chung, Dina Schneidman-Duhovny, Moshe Giladi, Hadas Newman, Yoni Haitin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Biomolecules
Subjects:
<i>cis</i>-prenyltransferase
computational modeling
hydrogen–deuterium exchange mass-spectrometry
small-angle x-ray scattering
enzyme kinetics
dhdds
Online Access:https://www.mdpi.com/2218-273X/9/11/660

Similar Items

Similar Items