Structure of cellular ESCRT-III spirals and their relationship to HIV budding

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this remains unclear. Using deep-etch electron microsc...

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Bibliographic Details
Main Authors: Anil G Cashikar, Soomin Shim, Robyn Roth, Michael R Maldazys, John E Heuser, Phyllis I Hanson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
ESCRT
deep-etch EM
HIV-1 budding
multivesicular body
endosome
Online Access:https://elifesciences.org/articles/02184

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