Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress

Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress

Hereditary spastic paraplegia (HSP) is a group of inherited neurodegenerative conditions that share a characteristic feature of degeneration of the longest axons within the corticospinal tract, which leads to progressive spasticity and weakness of the lower limbs. Mutations of over 70 genes produce...

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Bibliographic Details
Main Authors:	Sentiljana Gumeni, Chiara Vantaggiato, Monica Montopoli, Genny Orso
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Neuroscience
Subjects:	hereditary spastic paraplegia rapamycin N-acetyl cysteine salubrinal guanabenz methylene blue
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2021.660714/full

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