Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress

Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress

Hereditary spastic paraplegia (HSP) is a group of inherited neurodegenerative conditions that share a characteristic feature of degeneration of the longest axons within the corticospinal tract, which leads to progressive spasticity and weakness of the lower limbs. Mutations of over 70 genes produce...

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Bibliographic Details
Main Authors: Sentiljana Gumeni, Chiara Vantaggiato, Monica Montopoli, Genny Orso
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
hereditary spastic paraplegia
rapamycin
N-acetyl cysteine
salubrinal
guanabenz
methylene blue
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.660714/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.660714/full

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