Optimization of Nazarov Cyclization of 2,4-Dimethyl-1,5-diphenylpenta-1,4-dien-3-one in Deep Eutectic Solvents by a Design of Experiments Approach

Optimization of Nazarov Cyclization of 2,4-Dimethyl-1,5-diphenylpenta-1,4-dien-3-one in Deep Eutectic Solvents by a Design of Experiments Approach

The unprecedented Nazarov cyclization of a model divinyl ketone using phosphonium-based Deep Eutectic Solvents as sustainable non-innocent reaction media is described. A two-level full factorial Design of Experiments was conducted for elucidating the effect of the components of the eutectic mixture...

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Bibliographic Details
Main Authors: Stefano Nejrotti, Alberto Mannu, Marco Blangetti, Salvatore Baldino, Andrea Fin, Cristina Prandi
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
Nazarov reaction
Design of Experiments
deep eutectic solvents
surface responding analysis
Box-Behnken design
Online Access:https://www.mdpi.com/1420-3049/25/23/5726

Internet

https://www.mdpi.com/1420-3049/25/23/5726

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