Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II)
<p>Abstract</p> <p>Adjusting drug therapy to the individual, a common approach in clinical practice, has evolved from 1) dose adjustments based on clinical effects to 2) dose adjustments made in response to drug levels and, more recently, to 3) dose adjustments based on deoxyribonu...
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| Format: | Article |
| Language: | English |
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BMC
2004-08-01
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| Series: | Current Controlled Trials in Cardiovascular Medicine |
| Online Access: | http://cvm.controlled-trials.com/content/5/1/7 |
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doaj-783299245efd464684540e8ec9f8b5872020-11-24T22:04:44ZengBMCCurrent Controlled Trials in Cardiovascular Medicine1468-67082004-08-0151710.1186/1468-6708-5-7Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II)Pater Cornel<p>Abstract</p> <p>Adjusting drug therapy to the individual, a common approach in clinical practice, has evolved from 1) dose adjustments based on clinical effects to 2) dose adjustments made in response to drug levels and, more recently, to 3) dose adjustments based on deoxyribonucleic acid (DNA) sequencing of drug-metabolizing enzyme genes, suggesting a slow drug metabolism phenotype. This development dates back to the middle of the 20<sup>th </sup>century, when several different drugs were administered on the basis of individual plasma concentration measurements. Genetic control of drug metabolism was well established by the 1960s, and pharmakokinetic-based individualized therapy was in use by 1973.</p> http://cvm.controlled-trials.com/content/5/1/7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pater Cornel |
| spellingShingle |
Pater Cornel Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) Current Controlled Trials in Cardiovascular Medicine |
| author_facet |
Pater Cornel |
| author_sort |
Pater Cornel |
| title |
Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) |
| title_short |
Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) |
| title_full |
Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) |
| title_fullStr |
Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) |
| title_full_unstemmed |
Individualizing therapy – in search of approaches to maximize the benefit of drug treatment (II) |
| title_sort |
individualizing therapy – in search of approaches to maximize the benefit of drug treatment (ii) |
| publisher |
BMC |
| series |
Current Controlled Trials in Cardiovascular Medicine |
| issn |
1468-6708 |
| publishDate |
2004-08-01 |
| description |
<p>Abstract</p> <p>Adjusting drug therapy to the individual, a common approach in clinical practice, has evolved from 1) dose adjustments based on clinical effects to 2) dose adjustments made in response to drug levels and, more recently, to 3) dose adjustments based on deoxyribonucleic acid (DNA) sequencing of drug-metabolizing enzyme genes, suggesting a slow drug metabolism phenotype. This development dates back to the middle of the 20<sup>th </sup>century, when several different drugs were administered on the basis of individual plasma concentration measurements. Genetic control of drug metabolism was well established by the 1960s, and pharmakokinetic-based individualized therapy was in use by 1973.</p> |
| url |
http://cvm.controlled-trials.com/content/5/1/7 |
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AT patercornel individualizingtherapyinsearchofapproachestomaximizethebenefitofdrugtreatmentii |
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