Disulfide bridges remain intact while native insulin converts into amyloid fibrils.

Disulfide bridges remain intact while native insulin converts into amyloid fibrils.

Amyloid fibrils are β-sheet-rich protein aggregates commonly found in the organs and tissues of patients with various amyloid-associated diseases. Understanding the structural organization of amyloid fibrils can be beneficial for the search of drugs to successfully treat diseases associated with pro...

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Bibliographic Details
Main Authors: Dmitry Kurouski, Jacqueline Washington, Mehmet Ozbil, Rajeev Prabhakar, Alexander Shekhtman, Igor K Lednev
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3365881?pdf=render

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