Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent.

Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent.

Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were intramammarily challenged with Escherichia coli (E. coli) a...

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Bibliographic Details
Main Authors: Koen Breyne, Steven K Cool, Dieter Demon, Kristel Demeyere, Tom Vandenberghe, Peter Vandenabeele, Harald Carlsen, Wim Van Den Broeck, Niek N Sanders, Evelyne Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4146512?pdf=render

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