Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib

• Main Authors: Emole J, Talabi T, Pinilla-Ibarz J
• Format: Article
• Language: English
• Published: Dove Medical Press 2016-02-01
• Series: Biologics : Targets & Therapy
• Subjects: chronic myelogenous leukemia nilotinib tyrosine kinase inhibitor
• Online Access: https://www.dovepress.com/update-on-the-management-of-philadelphia-chromosome-positive-chronic-m-peer-reviewed-article-BTT

Josephine Emole,1 Taiwo Talabi,2 Javier Pinilla-Ibarz1 1Department of Malignant Hematology, 2Moffitt Program for Outreach Wellness Education and Resources, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA Abstract: Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl gene. The discovery of tyrosine kinase inhibitors (TKIs) revolutionized therapy for CML, such that durable response, increased overall survival, and increased progression-free survival of patients in chronic phase CML is now possible. Due to resistance and intolerance to imatinib, there was need for development of second- and third-generation TKIs for the treatment of CML. This review examines the role of nilotinib, an oral second-generation TKI, in the treatment of Philadelphia positive CML. The pharmacology, efficacy, and safety of nilotinib are critically evaluated. Patient-related issues, including tolerance, drug interactions, and quality of life issues are also examined. Keywords: chronic myelogenous leukemia, nilotinib, tyrosine kinase inhibitor