Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

Abstract Background Doxorubicin (DOX) is commonly used in the treatment of many types of cancers but its cardiotoxicity is limiting its clinical use. Beyond its anticoagulant action, enoxaparin (ENX), a low molecular weight heparin, has been shown to exert multiple pharmacological actions including...

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Bibliographic Details
Main Authors: Reem Ali Shaker, Samer Hassan Abboud, Hayder Chasib Assad, Najah Hadi
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
Doxorubicin
Cardiotoxicity
Low molecular weight heparin
Antioxidant
Inflammatory markers and caspase-3
Online Access:http://link.springer.com/article/10.1186/s40360-017-0184-z

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