Nanoparticles of cisplatin augment drug accumulations and inhibit multidrug resistance transporters in human glioblastoma cells

Nanoparticles of cisplatin augment drug accumulations and inhibit multidrug resistance transporters in human glioblastoma cells

Background: Cisplatin (CSP) is a potent anticancer drug widely used in treating glioblastoma multiforme (GBM). However, CSP's clinical efficacy in GBM contrasted with low therapeutic ratio, toxicity, and multidrug resistance (MDR). Therefore, we have developed a system for the active targeting...

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Bibliographic Details
Main Authors: Naseer Maliyakkal, Asmy Appadath Beeran, Nayanabhirama Udupa
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Saudi Pharmaceutical Journal
Subjects:
Cisplatin nanoparticles
Active drug targeting
Targeting multidrug resistance (MDR) transporters
Induction of Apoptosis
Drug uptake and accumulations
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016421001286

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