Variants of the Low Oxygen Sensors EGLN1 and HIF-1AN Associated with Acute Mountain Sickness

Variants of the Low Oxygen Sensors EGLN1 and HIF-1AN Associated with Acute Mountain Sickness

Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS). Here, we aimed to analyze single nucleotide polymorph...

Full description

Bibliographic Details
Main Authors:	Enhao Zhang, Jihang Zhang, Jun Jin, Jun Qin, Huijie Li, Lan Huang
Format:	Article
Language:	English
Published:	MDPI AG 2014-11-01
Series:	International Journal of Molecular Sciences
Subjects:	acute mountain sickness Egl nine homolog 1 (EGLN1) hypoxia-inducible factor 1-α inhibitor (HIF-1AN) single nucleotide polymorphism haplotype
Online Access:	http://www.mdpi.com/1422-0067/15/12/21777

Similar Items

Clinical observation of a patient with TMEM127 and EGLN1 gene variants, pheochromocytoma and pancreatic tumor
by: M. Yu. Yukina, et al.
Published: (2021-05-01)

An integrative functional genomics approach reveals EGLN1 as a novel therapeutic target in KRAS mutated lung adenocarcinoma
by: Francesca Reggiani, et al.
Published: (2021-04-01)

HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium
by: Laura Romanelli-Credrez, et al.
Published: (2020-02-01)

Association of EGLN1 genetic polymorphisms with SpO2 responses to acute hypobaric hypoxia in a Japanese cohort
by: Yoshiki Yasukochi, et al.
Published: (2018-04-01)

An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
by: Yukari Shirai, et al.
Published: (2021-06-01)

Molecular Characterization of EGLN1 Gene in Fast and Slow Moving Animals of Diverse Terrain
by: Rashid Saif, et al.
Published: (2018-08-01)

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study
by: Ji-Hang Zhang, et al.
Published: (2020-07-01)

HSPA1A gene polymorphism rs1008438 is associated with susceptibility to acute mountain sickness in Han Chinese individuals
by: Zhicheng Liu, et al.
Published: (2020-08-01)

The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression
by: Jaehyuk Pyo, et al.
Published: (2018-08-01)

IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells
by: Adrianna Moszyńska, et al.
Published: (2020-06-01)

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1
by: Helena Doktorova, et al.
Published: (2015-06-01)

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia
by: Xing-chen Ding, et al.
Published: (2021-06-01)

HIF-1α is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1α and NOTCH1 Signaling Pathways
by: Natacha Malu Miranda da Costa, et al.
Published: (2019-07-01)

Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia
by: Du, X., et al.
Published: (2022)

SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response
by: Shi-chun Du, et al.
Published: (2019-01-01)

JNK Contributes to Hif-1α Regulation in Hypoxic Neurons
by: Xanthi Antoniou, et al.
Published: (2009-12-01)

The Critical Impact of HIF-1a on Gastric Cancer Biology
by: Yoshihiko Kitajima, et al.
Published: (2013-01-01)

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α
by: Jianlong Wang, et al.
Published: (2021-06-01)

Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta‐analysis
by: Shulong Zhang, et al.
Published: (2019-10-01)

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity
by: Antonio Bouthelier, et al.
Published: (2020-12-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
by: Kiichi Hirota
Published: (2021-04-01)

The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain
by: Jaewoo Hong, et al.
Published: (2020-02-01)

Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
by: Gaurav Mrinal Sharma
Published: (2008-07-01)

Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia
by: Fatemeh Sadeghi, et al.
Published: (2020-06-01)

Specific Inhibition of HIF Activity: Can Peptides Lead the Way?
by: Ilias Mylonis, et al.
Published: (2021-01-01)

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling
by: Matthew J. Elder, et al.
Published: (2019-05-01)

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines
by: Mykyta I. Malkov, et al.
Published: (2021-09-01)

Effect of exercise on HIF-1 and VEGF signaling
by: Hideki Ohno, et al.
Published: (2012-08-01)

Mechanism of HIF-1α Promoting Malignant Development of Nasopharyngeal Carcinoma by Upregulating PD-L1 Under Hypoxic Conditions
by: JIANG Doudou, et al.
Published: (2021-06-01)

A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism
by: Ren Liu, et al.
Published: (2021-06-01)

Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine
by: Kiichi Hirota
Published: (2020-02-01)

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
by: Nakashima, Ryota
Published: (2018)

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
by: Shen-Han Lee, et al.
Published: (2021-09-01)

Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia
by: Carlos Sanhueza, et al.
Published: (2020-08-01)

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression
by: Chen-Ye Shi, et al.
Published: (2013-08-01)

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia
by: Tielong Liu, et al.
Published: (2018-05-01)

Hypoxia inhibits osteoclast differentiation by HIF-1α-mediated upregulation of NRP-1
by: LI Songtao, et al.
Published: (2019-06-01)

HIF-1 signaling: A key orchestrator of cancer radioresistance
by: Ruixue Huang, et al.
Published: (2020-03-01)

EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers
by: Marco Papale, et al.
Published: (2018-11-01)

Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the Development of Innovative Radiation Therapy
by: Masahiro Hiraoka, et al.
Published: (2011-09-01)

Cannot write session to /tmp/vufind_sessions/sess_t90n6evq4bie2qtvd0ir6b8t0k