Quantitative analysis of macular vessel density in noproliferative diabetic retinopathy by OCTA

• Main Authors: Zhan-Rong Zhang, Dong-Xiao Zang, Hua Liu, Yi Hao, Qiu-Jing Wang, Chen Song, Yu Wang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2020-10-01
• Series: Guoji Yanke Zazhi
• Subjects: vessel density; non-proliferative diabetic retinopathy; optical coherence tomography angiography
• Online Access: http://ies.ijo.cn/cn_publish/2020/10/202010025.pdf
• ISSN: 1672-5123; 1672-5123

AIM: To analyse the characteristic of macular microcirculation detected by optical coherence tomography angiography(OCTA)in nonproliferative diabetic retinopathy(NPDR).<p>METHODS: Vessel density of 3mm×3mm centered on the fovea(3mm×3mm VD), parafoveal vessel density(parafoveal VD)and foveal vessel density(foveal VD)were measured by OCTA in healthy people, NDR, mild NPDR, moderate NPDR, and severe NPDR groups. <p>RESULTS: Deep 3mm×3mm VD, deep parafoveal VD and deep foveal VD were decreased gradually in groups. There was statistically significant difference between moderate NPDR, severe NPDR and others in deep 3mm×3mm VD and parafoveal VD(<i>P</i><0.01). There was statistically significant difference between severe NPDR and control group in deep foveal VD(<i>P</i>=0.006). Superficial 3mm×3mm VD and superficial parafoveal VD are statistically significant in groups. There was statistically significant difference between moderate NPDR group and control group in superficial 3mm×3mm VD and parafoveal VD(<i>P</i><0.01). There was statistically significant difference between severe NPDR group and others except moderate NPDR group in superficial 3mm×3mm VD, parafoveal VD(<i>P</i><0.01). There was a significant correlation of deep and superficial 3mm×3mm VD,deep and superficial parafoveal VD, deep parafoveal VD with VA.<p>CONCLUSION: Deep vessel density decreased more significantly in moderate NPDR and severe NPDR groups and deep parafoveal vessel density might be a potential biomarker of DR.