The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver disease (NAFLD). In the livers of mice suffering from NAFLD, NK cells are less able to degranulate, express low...

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Bibliographic Details
Main Authors: Antonia O. Cuff, Francesca Sillito, Simone Dertschnig, Andrew Hall, Tu Vinh Luong, Ronjon Chakraverty, Victoria Male
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
NK cells
ILC1
obesity
NAFLD
immunometabolism
TGFβ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02180/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02180/full

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