Ubiquitin and Ubiquitin-Like Modifications of the p53 Family

Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of the...

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Main Authors:	Ian R. Watson, Meredith S. Irwin
Format:	Article
Language:	English
Published:	Elsevier 2006-08-01
Series:	Neoplasia: An International Journal for Oncology Research
Subjects:	p63 p73 ubiquitin SUMO NEDD8
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558606800047

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spelling	doaj-77edd734683544e8adfeaccd233b0db12020-11-25T00:05:05ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022006-08-018865566610.1593/neo.06439Ubiquitin and Ubiquitin-Like Modifications of the p53 FamilyIan R. Watson0Meredith S. Irwin1Cancer Research Program and Division of Hematology-Oncology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8Cancer Research Program and Division of Hematology-Oncology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8 Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8. http://www.sciencedirect.com/science/article/pii/S1476558606800047p63p73ubiquitinSUMONEDD8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ian R. Watson Meredith S. Irwin
spellingShingle	Ian R. Watson Meredith S. Irwin Ubiquitin and Ubiquitin-Like Modifications of the p53 Family Neoplasia: An International Journal for Oncology Research p63 p73 ubiquitin SUMO NEDD8
author_facet	Ian R. Watson Meredith S. Irwin
author_sort	Ian R. Watson
title	Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
title_short	Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
title_full	Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
title_fullStr	Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
title_full_unstemmed	Ubiquitin and Ubiquitin-Like Modifications of the p53 Family
title_sort	ubiquitin and ubiquitin-like modifications of the p53 family
publisher	Elsevier
series	Neoplasia: An International Journal for Oncology Research
issn	1476-5586 1522-8002
publishDate	2006-08-01
description	Regulation of p53 by the ubiquitin-proteasomal pathway has been studied considerably. Studies have also demonstrated that the ubiquitin-like proteins SUMO-1 and NEDD8 modify p53. Similarly, p63 and p73 are subject to regulation by ubiquitin and ubiquitin-like modifications, and perturbations of these pathways in the regulation of the p53 family have been implicated in tumorigenesis and developmental abnormalities. Here, we provide an overview of the current understanding of the regulation of the p53 family by covalent modification by ubiquitin, SUMO-1, and NEDD8.
topic	p63 p73 ubiquitin SUMO NEDD8
url	http://www.sciencedirect.com/science/article/pii/S1476558606800047
work_keys_str_mv	AT ianrwatson ubiquitinandubiquitinlikemodificationsofthep53family AT meredithsirwin ubiquitinandubiquitinlikemodificationsofthep53family
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Ubiquitin and Ubiquitin-Like Modifications of the p53 Family

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