The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary

The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary

The intestinal epithelium does not function in isolation, but interacts with many components including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium interactions requires multidisciplinary approaches to uncover cells involved, mechanisms used, and the ultimate influen...

Full description

Bibliographic Details
Main Authors: Kathleen T. Walsh, Anne E. Zemper
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X19300645
id doaj-77eaf451d2704de29fea9daf6af2e5ef
record_format Article
spelling doaj-77eaf451d2704de29fea9daf6af2e5ef2020-11-25T01:35:54ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2019-01-0183369378The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummaryKathleen T. Walsh0Anne E. Zemper1Institute of Molecular Biology, University of Oregon, Eugene, Oregon; Institute of Neuroscience, University of Oregon, Eugene, Oregon; Department of Biology, University of Oregon, Eugene, OregonInstitute of Molecular Biology, University of Oregon, Eugene, Oregon; Department of Biology, University of Oregon, Eugene, Oregon; Correspondence Address correspondence to: Anne E. Zemper, PhD, University of Oregon, 218 Streisinger Hall, 1370 Franklin Boulevard, Eugene, Oregon 97401. fax: (541) 346–6056.The intestinal epithelium does not function in isolation, but interacts with many components including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium interactions requires multidisciplinary approaches to uncover cells involved, mechanisms used, and the ultimate influence on intestinal physiology. This review is intended to serve as a reference for epithelial biologists interested in studying these interactions. With this in mind, this review aims to summarize the basic anatomy of the epithelium and ENS, mechanisms by which they interact, and techniques used to study these interactions. We highlight in vitro, ex vivo and in vivo techniques. Additionally, ENS influence on epithelial proliferation and gene expression within stem and differentiated cells as well as gastrointestinal cancer are discussed.http://www.sciencedirect.com/science/article/pii/S2352345X19300645
collection DOAJ
language English
format Article
sources DOAJ
author Kathleen T. Walsh
Anne E. Zemper
spellingShingle Kathleen T. Walsh
Anne E. Zemper
The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
Cellular and Molecular Gastroenterology and Hepatology
author_facet Kathleen T. Walsh
Anne E. Zemper
author_sort Kathleen T. Walsh
title The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
title_short The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
title_full The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
title_fullStr The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
title_full_unstemmed The Enteric Nervous System for Epithelial Researchers: Basic Anatomy, Techniques, and Interactions With the EpitheliumSummary
title_sort enteric nervous system for epithelial researchers: basic anatomy, techniques, and interactions with the epitheliumsummary
publisher Elsevier
series Cellular and Molecular Gastroenterology and Hepatology
issn 2352-345X
publishDate 2019-01-01
description The intestinal epithelium does not function in isolation, but interacts with many components including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium interactions requires multidisciplinary approaches to uncover cells involved, mechanisms used, and the ultimate influence on intestinal physiology. This review is intended to serve as a reference for epithelial biologists interested in studying these interactions. With this in mind, this review aims to summarize the basic anatomy of the epithelium and ENS, mechanisms by which they interact, and techniques used to study these interactions. We highlight in vitro, ex vivo and in vivo techniques. Additionally, ENS influence on epithelial proliferation and gene expression within stem and differentiated cells as well as gastrointestinal cancer are discussed.
url http://www.sciencedirect.com/science/article/pii/S2352345X19300645
work_keys_str_mv AT kathleentwalsh theentericnervoussystemforepithelialresearchersbasicanatomytechniquesandinteractionswiththeepitheliumsummary
AT anneezemper theentericnervoussystemforepithelialresearchersbasicanatomytechniquesandinteractionswiththeepitheliumsummary
AT kathleentwalsh entericnervoussystemforepithelialresearchersbasicanatomytechniquesandinteractionswiththeepitheliumsummary
AT anneezemper entericnervoussystemforepithelialresearchersbasicanatomytechniquesandinteractionswiththeepitheliumsummary
_version_ 1725065457258463232

Similar Items