TREATMENT ESTIMATION OF DIABETIC NEPHROPATHY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS BY ANGIOTENSIN CONVERTING ENZYME INHIBITORS

• Main Authors: V.N. Panfilova, T.E. Taranushenko, O.A. Terent’eva
• Format: Article
• Language: English
• Published: Paediatrician Publishers, LLC 2008-11-01
• Series: Pediatričeskaâ Farmakologiâ
• Online Access: https://pf.spr-journal.ru/jour/article/view/806
• ISSN: 1727-5776; 2500-3089

The researchers analyzed the rate and intensity of albuminuria among children and teenagers with type 1 diabetes mellitus (dm1). They studied 4 groups of patients with various diabetes duration: 3 years, from 3 to 5 years, from 5 to 10 years and over 10 years. In creased renal excretion of albumin was registered across all the groups of patients along with the increase of the rate and intensity provided diabetes duration is over 10 years. Subject to the approved criteria, diabetic nephropathy was diagnosed in 15,4% of patients, whereas 9 of 55 children with diabetes have had dm1 for less than 3 years. The median of the micro albuminuria debut falls into the dm1 duration of 4 years, while proteinuria begin in 6 years of the disease at the mean. Angiotensin converting enzyme inhibitors based therapy for 6 months proved to be efficient among children with microalbuminuria. A more intense effect has been obtained when the treatment course was for 1 year. Once the medication was canceled the intensity of albuminuria increased for the next six months again. Among the patients with proteinuria, the treatment by the angiotensin converting enzyme inhibitors proved to be insufficiently efficient. The results of the present analysis showed the efficiency of the angiotensin converting enzyme inhibitors based therapy at the preclinical diabetes stages, confirmed irreversibility of the nephropathy advance against initially high excretion of albumin with urine irrespective of the disease stage and defined the necessity to start the angiotensin converting enzyme inhibitors based therapy at an early stage to achieve the long term results.Key words: type 1 diabetes mellitus, children, diabetic nephropathy, albuminuria, proteinuria, angiotensin converting enzyme inhibitors.