TP53 mutations in circulating tumor DNA in advanced epidermal growth factor receptor-mutant lung adenocarcinoma patients treated with gefitinib

TP53 mutations in circulating tumor DNA in advanced epidermal growth factor receptor-mutant lung adenocarcinoma patients treated with gefitinib

Tumor protein p53 (TP53) is a tumor suppressor gene and TP53 mutations are associated with poor prognosis in non-small cell lung cancer. However, the in-depth classification of TP53 and its relationship with treatment response and prognosis in epidermal growth factor receptor (EGFR)-mutant tumors tr...

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Bibliographic Details
Main Authors: Ruofei Yu, Hua Bai, Tangai Li, Bingyu Gao, Jiefei Han, Geyun Chang, Pei Zhang, Kailun Fei, Xiran He, Jie Wang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Translational Oncology
Subjects:
Epidermal growth factor receptor (EGFR)
Tumor protein p53 (TP53)
Lung adenocarcinoma
Co-mutations
ctDNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001558

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