Twist1- and Twist2-haploinsufficiency results in reduced bone formation.

Twist1- and Twist2-haploinsufficiency results in reduced bone formation.

Twist1 and Twist2 are highly homologous bHLH transcription factors that exhibit extensive highly overlapping expression profiles during development. While both proteins have been shown to inhibit osteogenesis, only Twist1 haploinsufficiency is associated with the premature synostosis of cranial sutu...

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Bibliographic Details
Main Authors: Yanyu Huang, Tian Meng, Suzhen Wang, Hua Zhang, Gabriele Mues, Chunlin Qin, Jian Q Feng, Rena N D'Souza, Yongbo Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4074031?pdf=render

Internet

http://europepmc.org/articles/PMC4074031?pdf=render

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