Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells

Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in Human Airway Epithelial Cells

The function of cystic fibrosis transmembrane conductance regulator (CFTR) channels is crucial in human airways. However unfortunately, chronic Pseudomonas aeruginosa infection has been shown to impair CFTR proteins in non-CF airway epithelial cells (AEC) and to alter the efficiency of new treatment...

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Bibliographic Details
Main Authors: Émilie Maillé, Manon Ruffin, Damien Adam, Hatem Messaoud, Shantelle L. Lafayette, Geoffrey McKay, Dao Nguyen, Emmanuelle Brochiero
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cystic fibrosis
P. aeruginosa
infection
CFTR
Vx-809
correctors
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00470/full

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