NS3 Protease from Hepatitis C Virus: Biophysical Studies on an Intrinsically Disordered Protein Domain

NS3 Protease from Hepatitis C Virus: Biophysical Studies on an Intrinsically Disordered Protein Domain

The nonstructural protein 3 (NS3) from the hepatitis C virus (HCV) is responsible for processing the non-structural region of the viral precursor polyprotein in infected hepatic cells. NS3 protease activity, located at the N-terminal domain, is a zinc-dependent serine protease. A zinc ion, required...

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Bibliographic Details
Main Authors: Adrian Velazquez-Campoy, Olga Abian, Carlos Marcuello, Anabel Lostao, Sonia Vega, Jose L. Neira
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:International Journal of Molecular Sciences
Subjects:
NS3 protease
protein folding and stability
ligand binding
conformational landscape
intrinsically disordered protein
Online Access:http://www.mdpi.com/1422-0067/14/7/13282

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