Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results

Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results

Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asym...

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Main Authors: Petramala Luigi, Formicuccia Maria Chiara, Zinnamosca Laura, Marinelli Cristiano, Cilenti Giuseppina, Colangelo Luciano, Panzironi Giuseppe, Cerci Sabrina, Sciomer Susanna, Ciardi Antonio, Cavallaro Giuseppe, De Toma Giorgio, Letizia Claudio
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2012/408295
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spelling doaj-77cc37bef083409aae1433b9c38462e92020-11-25T00:34:44ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/408295408295Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary ResultsPetramala Luigi0Formicuccia Maria Chiara1Zinnamosca Laura2Marinelli Cristiano3Cilenti Giuseppina4Colangelo Luciano5Panzironi Giuseppe6Cerci Sabrina7Sciomer Susanna8Ciardi Antonio9Cavallaro Giuseppe10De Toma Giorgio11Letizia Claudio12Secondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalyHospital “San Sebastiano” of Frascati, Rome, ItalyDepartment of Cardiovascular, Respiratory and Morphological Sciences, University of Rome “Sapienza”, Rome, ItalyDepartment of Surgery “P. Valdoni”, University of Rome “Sapienza”, Rome, ItalyDepartment of Surgery “P. Valdoni”, University of Rome “Sapienza”, Rome, ItalyDepartment of Surgery “P. Valdoni”, University of Rome “Sapienza”, Rome, ItalySecondary Hypertension Unit, Department of Internal Medicine and Medical Specialties, University of Rome “Sapienza”, Rome, ItalyBackground. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56±6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55±4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55±6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and “non-dipping phenomenon.” Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.http://dx.doi.org/10.1155/2012/408295
collection DOAJ
language English
format Article
sources DOAJ
author Petramala Luigi
Formicuccia Maria Chiara
Zinnamosca Laura
Marinelli Cristiano
Cilenti Giuseppina
Colangelo Luciano
Panzironi Giuseppe
Cerci Sabrina
Sciomer Susanna
Ciardi Antonio
Cavallaro Giuseppe
De Toma Giorgio
Letizia Claudio
spellingShingle Petramala Luigi
Formicuccia Maria Chiara
Zinnamosca Laura
Marinelli Cristiano
Cilenti Giuseppina
Colangelo Luciano
Panzironi Giuseppe
Cerci Sabrina
Sciomer Susanna
Ciardi Antonio
Cavallaro Giuseppe
De Toma Giorgio
Letizia Claudio
Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
International Journal of Endocrinology
author_facet Petramala Luigi
Formicuccia Maria Chiara
Zinnamosca Laura
Marinelli Cristiano
Cilenti Giuseppina
Colangelo Luciano
Panzironi Giuseppe
Cerci Sabrina
Sciomer Susanna
Ciardi Antonio
Cavallaro Giuseppe
De Toma Giorgio
Letizia Claudio
author_sort Petramala Luigi
title Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
title_short Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
title_full Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
title_fullStr Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
title_full_unstemmed Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results
title_sort arterial hypertension, metabolic syndrome and subclinical cardiovascular organ damage in patients with asymptomatic primary hyperparathyroidism before and after parathyroidectomy: preliminary results
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2012-01-01
description Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56±6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55±4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55±6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and “non-dipping phenomenon.” Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.
url http://dx.doi.org/10.1155/2012/408295
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