Diabetes Mellitus Directs NKT Cells Toward Type 2 and Regulatory Phenotype / Diabetes Melitus Usmerava Diferencijaciju NKT Celija U Pravcu Tip 2 I Regulatornog Fenotipa

Diabetes Mellitus Directs NKT Cells Toward Type 2 and Regulatory Phenotype / Diabetes Melitus Usmerava Diferencijaciju NKT Celija U Pravcu Tip 2 I Regulatornog Fenotipa

Diabetes mellitus is chronic disorder characterized by hyperglycaemia. Hyperglycaemia induces mitochondrial dysfunction, enhances oxidative stress and thus promotes reactive oxygen species (ROS) production. Earlier studies suggested that reactive oxygen species (ROS) are involved in the pathogenesis...

Full description

Bibliographic Details
Main Authors: Gajovic Nevena, Jovanovic Ivan, Ilic Aleksandar, Jeremic Nevena, Jakovljevic Vladimir, Arsenijevic Nebojsa, Lukic Miodrag L.
Format: Article
Language:English
Published: Sciendo 2016-03-01
Series:Serbian Journal of Experimental and Clinical Research
Subjects:
diabetes
hyperglycaemia
oxidative stress
nkt cells
Online Access:https://doi.org/10.1515/sjecr-2016-0005
Description
Summary:Diabetes mellitus is chronic disorder characterized by hyperglycaemia. Hyperglycaemia induces mitochondrial dysfunction, enhances oxidative stress and thus promotes reactive oxygen species (ROS) production. Earlier studies suggested that reactive oxygen species (ROS) are involved in the pathogenesis of many diseases. Previous studies have revealed that hyperglycaemia changes the functional phenotype of monocytes, macrophages, neutrophils, NK cells and CD8+ T cells. The aim of this study was to investigate whether diabetes affects the functional phenotype of NKT cells.
ISSN:1820-8665
2335-075X

Similar Items