MARKERS OF SYSTEMIC INFLAMMATION AND MATRIX METALLOPROTEINASE / TISSUE INHIBITOR OF METALLOPROTEINASES SYSTEM AT DIFFERENT STAGES OF CHRONIC HEART FAILURE

MARKERS OF SYSTEMIC INFLAMMATION AND MATRIX METALLOPROTEINASE / TISSUE INHIBITOR OF METALLOPROTEINASES SYSTEM AT DIFFERENT STAGES OF CHRONIC HEART FAILURE

Abstract. A comparative analysis of endotoxinemia grade, tumor necrosis factor α, C-reactive protein, sEselectin, matrix metalloproteinase-9 (MMP) and tissue inhibitor of metalloproteinases-4 (TIMP) levels was performed in a group of patients with chronic heart failure (CHF). An association has been...

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Bibliographic Details
Main Authors: E. N. Egorova, M. A. Kuzmina, V. V. Masur, M. N. Kalinkin, E. S. Mazur
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
chronic heart failure pathogenesis
chronic systemic inflammation
endotoxin
proinflammatory cytokines
matrix metalloproteinases
Online Access:https://www.mimmun.ru/mimmun/article/view/314
Description
Summary:Abstract. A comparative analysis of endotoxinemia grade, tumor necrosis factor α, C-reactive protein, sEselectin, matrix metalloproteinase-9 (MMP) and tissue inhibitor of metalloproteinases-4 (TIMP) levels was performed in a group of patients with chronic heart failure (CHF). An association has been shown between CHF progression and activation of systemic inflammation, like as with an imbalance in MMP/TIMP system. These alterations may represent a factor of structural disturbances in myocardial extracellular matrix, and promote a compartmental heart remodeling in this disorder.
ISSN:1563-0625
2313-741X

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