Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease

Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease

There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer’s disease (AD). Early prediction and diagnosis of AD might be improved by the detection of a proteolytic dysfunction in extracts from cultured AD fibroblasts, producing altered isoelectr...

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Bibliographic Details
Main Authors: Alessandra Mocali, Nunzia Della Malva, Claudia Abete, Vito Antonio Mitidieri Costanza, Antonio Bavazzano, Vieri Boddi, Luis Sanchez, Sandra Dessì, Alessandra Pani, Francesco Paoletti
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.1155/2014/520152

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