Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats

Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats

Dexmedetomidine (DEX) is an α2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats...

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Main Authors: Liu Xianbao, Zhan Hong, Zeng Xu, Zhang Chunfang, Chen Dunjin
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/627831
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spelling doaj-77bca0df7fc247f49667b0b9315fa7e32020-11-24T21:03:05ZengHindawi LimitedMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/627831627831Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in RatsLiu Xianbao0Zhan Hong1Zeng Xu2Zhang Chunfang3Chen Dunjin4Department of Anesthesiology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Anesthesiology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Detroit Medical Center, Harper University Hospital, School of Medicine, Wayne State University, 3990 John R, Detroit, MI 48201, USADepartment of Gynecology and Obstetrics, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Gynecology and Obstetrics, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, ChinaDexmedetomidine (DEX) is an α2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats. In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS. It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.http://dx.doi.org/10.1155/2013/627831
collection DOAJ
language English
format Article
sources DOAJ
author Liu Xianbao
Zhan Hong
Zeng Xu
Zhang Chunfang
Chen Dunjin
spellingShingle Liu Xianbao
Zhan Hong
Zeng Xu
Zhang Chunfang
Chen Dunjin
Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
Mediators of Inflammation
author_facet Liu Xianbao
Zhan Hong
Zeng Xu
Zhang Chunfang
Chen Dunjin
author_sort Liu Xianbao
title Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
title_short Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
title_full Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
title_fullStr Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
title_full_unstemmed Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats
title_sort dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2013-01-01
description Dexmedetomidine (DEX) is an α2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats. In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS. It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.
url http://dx.doi.org/10.1155/2013/627831
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AT zhanhong dexmedetomidinereducedcytokinereleaseduringpostpartumbleedinginducedmultipleorgandysfunctionsyndromeinrats
AT zengxu dexmedetomidinereducedcytokinereleaseduringpostpartumbleedinginducedmultipleorgandysfunctionsyndromeinrats
AT zhangchunfang dexmedetomidinereducedcytokinereleaseduringpostpartumbleedinginducedmultipleorgandysfunctionsyndromeinrats
AT chendunjin dexmedetomidinereducedcytokinereleaseduringpostpartumbleedinginducedmultipleorgandysfunctionsyndromeinrats
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