Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance

Hyaluronan (HA), a glycosaminoglycan located in the extracellular matrix, is important in embryo development, inflammation, wound healing and cancer. There is an extensive body of research demonstrating the role of HA in all stages of cancer, from initiation to relapse and therapy resistance. HA int...

Full description

Bibliographic Details
Main Authors: Zoe K. Price, Noor A. Lokman, Carmela Ricciardelli
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/10/12/482
id doaj-77b8bd219c8d4147a5cb84c34151ac45
record_format Article
spelling doaj-77b8bd219c8d4147a5cb84c34151ac452020-11-24T20:51:34ZengMDPI AGCancers2072-66942018-12-01101248210.3390/cancers10120482cancers10120482Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy ResistanceZoe K. Price0Noor A. Lokman1Carmela Ricciardelli2Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, South Australia 5000, AustraliaDiscipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, South Australia 5000, AustraliaDiscipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, South Australia 5000, AustraliaHyaluronan (HA), a glycosaminoglycan located in the extracellular matrix, is important in embryo development, inflammation, wound healing and cancer. There is an extensive body of research demonstrating the role of HA in all stages of cancer, from initiation to relapse and therapy resistance. HA interacts with multiple cell surface receptors, including CD44, receptor for hyaluronan mediated motility (RHAMM) and intracellular signaling pathways, including receptor tyrosine kinase pathways, to promote the survival and proliferation of cancer cells. Additionally, HA promotes the formation of cancer stem cell (CSC) populations, which are hypothesized to be responsible for the initiation of tumors and therapy resistance. Recent studies have identified that the molecular weight of HA plays differing roles on both normal and cancer cell behavior. This review explores the role of HA in cancer progression and therapy resistance and how its molecular weight is important in regulating CSC populations, epithelial to mesenchymal transition (EMT), ATP binding cassette (ABC) transporter expression and receptor tyrosine kinase pathways.https://www.mdpi.com/2072-6694/10/12/482hyaluronancancermolecular weighttherapy resistancecancer stem cellsoligosaccharidestyrosine kinase
collection DOAJ
language English
format Article
sources DOAJ
author Zoe K. Price
Noor A. Lokman
Carmela Ricciardelli
spellingShingle Zoe K. Price
Noor A. Lokman
Carmela Ricciardelli
Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
Cancers
hyaluronan
cancer
molecular weight
therapy resistance
cancer stem cells
oligosaccharides
tyrosine kinase
author_facet Zoe K. Price
Noor A. Lokman
Carmela Ricciardelli
author_sort Zoe K. Price
title Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
title_short Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
title_full Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
title_fullStr Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
title_full_unstemmed Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance
title_sort differing roles of hyaluronan molecular weight on cancer cell behavior and chemotherapy resistance
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2018-12-01
description Hyaluronan (HA), a glycosaminoglycan located in the extracellular matrix, is important in embryo development, inflammation, wound healing and cancer. There is an extensive body of research demonstrating the role of HA in all stages of cancer, from initiation to relapse and therapy resistance. HA interacts with multiple cell surface receptors, including CD44, receptor for hyaluronan mediated motility (RHAMM) and intracellular signaling pathways, including receptor tyrosine kinase pathways, to promote the survival and proliferation of cancer cells. Additionally, HA promotes the formation of cancer stem cell (CSC) populations, which are hypothesized to be responsible for the initiation of tumors and therapy resistance. Recent studies have identified that the molecular weight of HA plays differing roles on both normal and cancer cell behavior. This review explores the role of HA in cancer progression and therapy resistance and how its molecular weight is important in regulating CSC populations, epithelial to mesenchymal transition (EMT), ATP binding cassette (ABC) transporter expression and receptor tyrosine kinase pathways.
topic hyaluronan
cancer
molecular weight
therapy resistance
cancer stem cells
oligosaccharides
tyrosine kinase
url https://www.mdpi.com/2072-6694/10/12/482
work_keys_str_mv AT zoekprice differingrolesofhyaluronanmolecularweightoncancercellbehaviorandchemotherapyresistance
AT nooralokman differingrolesofhyaluronanmolecularweightoncancercellbehaviorandchemotherapyresistance
AT carmelaricciardelli differingrolesofhyaluronanmolecularweightoncancercellbehaviorandchemotherapyresistance
_version_ 1716801796030070784