Liver-derived ketone bodies are necessary for food anticipation

Liver-derived ketone bodies are necessary for food anticipation

Food anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent pro...

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Main Authors: Rohit Chavan, Céline Feillet, Sara S. Fonseca Costa, James E. Delorme, Takashi Okabe, Jürgen A. Ripperger, Urs Albrecht
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10580
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spelling doaj-77b85e39911340e4b93f1f36a10c90872021-05-11T11:17:06ZengNature Publishing GroupNature Communications2041-17232016-02-017111010.1038/ncomms10580Liver-derived ketone bodies are necessary for food anticipationRohit Chavan0Céline Feillet1Sara S. Fonseca Costa2James E. Delorme3Takashi Okabe4Jürgen A. Ripperger5Urs Albrecht6Department of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgDepartment of Biology, Unit of Biochemistry, University of FribourgFood anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent processing in the brain.https://doi.org/10.1038/ncomms10580
collection DOAJ
language English
format Article
sources DOAJ
author Rohit Chavan
Céline Feillet
Sara S. Fonseca Costa
James E. Delorme
Takashi Okabe
Jürgen A. Ripperger
Urs Albrecht
spellingShingle Rohit Chavan
Céline Feillet
Sara S. Fonseca Costa
James E. Delorme
Takashi Okabe
Jürgen A. Ripperger
Urs Albrecht
Liver-derived ketone bodies are necessary for food anticipation
Nature Communications
author_facet Rohit Chavan
Céline Feillet
Sara S. Fonseca Costa
James E. Delorme
Takashi Okabe
Jürgen A. Ripperger
Urs Albrecht
author_sort Rohit Chavan
title Liver-derived ketone bodies are necessary for food anticipation
title_short Liver-derived ketone bodies are necessary for food anticipation
title_full Liver-derived ketone bodies are necessary for food anticipation
title_fullStr Liver-derived ketone bodies are necessary for food anticipation
title_full_unstemmed Liver-derived ketone bodies are necessary for food anticipation
title_sort liver-derived ketone bodies are necessary for food anticipation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Food anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent processing in the brain.
url https://doi.org/10.1038/ncomms10580
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AT celinefeillet liverderivedketonebodiesarenecessaryforfoodanticipation
AT sarasfonsecacosta liverderivedketonebodiesarenecessaryforfoodanticipation
AT jamesedelorme liverderivedketonebodiesarenecessaryforfoodanticipation
AT takashiokabe liverderivedketonebodiesarenecessaryforfoodanticipation
AT jurgenaripperger liverderivedketonebodiesarenecessaryforfoodanticipation
AT ursalbrecht liverderivedketonebodiesarenecessaryforfoodanticipation
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