Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario

Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario

Alzheimer's disease (AD) manifests as neuronal loss. On the premise of Grb2 overexpression in AD mouse brain and brain tissues of AD patients, our study primarily focuses on the stability of cytoskeletal proteins in the context of degenerative AD-like conditions. Two predominant molecular featu...

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Bibliographic Details
Main Authors: Piyali Majumder, Kasturi Roy, Brijesh Kumar Singh, Nihar Ranjan Jana, Debashis Mukhopadhyay
Format: Article
Language:English
Published: The Company of Biologists 2017-05-01
Series:Disease Models & Mechanisms
Subjects:
Alzheimer's disease
APP/PS1 mouse model
Growth factor receptor bound protein 2
GRB2
Cytoskeleton
β-amyloid
β-amyloid protein precursor intracellular domain
AICD
Online Access:http://dmm.biologists.org/content/10/5/655

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