Intrarenal Oxidative Stress and Augmented Angiotensinogen are Precedent to Renal Injury in Zucker Diabetic Fatty Rats

<p>The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was...

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Bibliographic Details
Main Author: Yuki Suzaki, Yuri Ozawa, Hiroyuki Kobori
Format: Article
Language:English
Published: Ivyspring International Publisher 2007-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v03p0040.htm