Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA IX expression of seven previously synthesised sulphonamide inhibitors, with high affinity for CA IX, as well as their effect on the prolifera...

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Bibliographic Details
Main Authors: Ismail Koyuncu, Ataman Gonel, Abdurrahim Kocyigit, Ebru Temiz, Mustafa Durgun, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase IX
sulphonamide
apoptosis
reactive oxygen species
anticancer agent
Online Access:http://dx.doi.org/10.1080/14756366.2018.1481403

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