IGF-I, IGF-II and insulin stimulate different gene expression responses through binding to the IGF-I receptor.

IGF-I, IGF-II and insulin stimulate different gene expression responses through binding to the IGF-I receptor.

Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor. Although the insulin receptor is the main physiological receptor for...

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Bibliographic Details
Main Authors: Soetkin eVersteyhe, Birgit eKlaproth, Rehannah eBorup, Jane ePalsgaard, Maja eJensen, Steven G. Gray, Pierre eDe Meyts
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Endocrinology
Subjects:
Insulin
Differential signaling
IGF
IGF-I receptor
microarray gene expression
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00098/full

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