An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells

An Experimentally Induced Mutation in the UBA Domain of p62 Changes the Sensitivity of Cisplatin by Up-Regulating HK2 Localisation on the Mitochondria and Increasing Mitophagy in A2780 Ovarian Cancer Cells

The study of cisplatin sensitivity is the key to the development of ovarian cancer treatment strategies. Mitochondria are one of the main targets of cisplatin, its self-clearing ability plays an important role in determining the fate of ovarian cancer cells. First, we proved that the sensitivity of...

Full description

Bibliographic Details
Main Authors: Sihang Yu, Xiaoyu Yan, Rui Tian, Long Xu, Yuanxin Zhao, Liankun Sun, Jing Su
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
mitophagy
UBA
p62
cisplatin
apoptosis
ovarian cancer
Online Access:https://www.mdpi.com/1422-0067/22/8/3983

Similar Items

Similar Items