Hexobarbital Sleep Test for Predicting the Susceptibility or Resistance to Experimental Posttraumatic Stress Disorder

Hexobarbital Sleep Test for Predicting the Susceptibility or Resistance to Experimental Posttraumatic Stress Disorder

Hexobarbital sleep test (HST) was performed in male Wistar rats (hexobarbital 60 mg/kg, i.p.) 30 days prior to stress exposure. Based on the duration of hexobarbital-induced sleep, rats were divided into two groups, animals with high intensity (fast metabolizers (FM), sleep duration <15 min) or l...

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Bibliographic Details
Main Authors: Maria Komelkova, Eugenia Manukhina, H. Fred Downey, Alexey Sarapultsev, Olga Cherkasova, Viacheslav Kotomtsev, Pavel Platkovskiy, Stanislav Fedorov, Petr Sarapultsev, Olga Tseilikman, David Tseilikman, Vadim Tseilikman
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
hexobarbital sleep test
posttraumatic stress disorder
corticosterone
glucocorticoid metabolism
resilience
Online Access:https://www.mdpi.com/1422-0067/21/16/5900

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