Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation

Reversal of the anticoagulant and anti-hemostatic effect of low molecular weight heparin by direct prothrombin activation

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Lopap, found in the bristles of Lonomia obliqua caterpillar, is the first exogenous prothrombin activator that shows serine protease-like activity, independent of prothrombinase components and unique lipocalin reported to interfere with hemostasis mechanisms. To assess the action of an exogenous pro...

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Bibliographic Details
Main Authors: S.A. Andrade, L.C. Carrijo-Carvalho, L.A.M. Peceguini, L. Wlian, A.C. Sato, C. Luchiari, E.D. Silva, F.H.A. Maffei, A.M. Chudzinski-Tavassi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-10-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Prothrombin activation
Procoagulant
Exogenous hemostatic factor
rLopap
Bleeding
Anticoagulant
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000007&lng=en&tlng=en

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