Synthesis and Antitumor Activity of a Series of Novel 1-Oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione Derivatives

Synthesis and Antitumor Activity of a Series of Novel 1-Oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione Derivatives

A series of novel 1-oxa-4-azaspiro[4.5]deca-6,9-diene-3,8-diones were designed and synthesized by using 4-aminophenol and α-glycolic acid or lactic acid as starting materials in three or four steps. The key step is the metal-catalyzed oxidative cyclization of the amide to 1-oxa-4-azaspiro[...

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Bibliographic Details
Main Authors: Ze Yang, Qiu Zhong, Shilong Zheng, Guangdi Wang, Ling He
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
1-oxa-4-azaspiro[4.5]deca-6,9-diene-3,8-dione
intramolecular oxidation
antitumor activity
Online Access:http://www.mdpi.com/1420-3049/24/5/936

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http://www.mdpi.com/1420-3049/24/5/936

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