Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved

Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved

The pathological implication of amyloid precursor protein (APP) in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide. However, the physiological functions of APP are still poorly understood. APP is considered a multimodal protein due to its...

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Bibliographic Details
Main Authors: Raquel Coronel, Charlotte Palmer, Adela Bernabeu-Zornoza, María Monteagudo, Andreea Rosca, Alberto Zambrano, Isabel Liste
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
amyloid precursor protein; APP; soluble APP alpha; soluble APP beta; amyloid beta peptide; APP intracellular domain; neural stem cells; neural progenitor cells; neurogenesis; signaling pathways
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=10;spage=1661;epage=1671;aulast=Coronel

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