Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms

Multipotent adult progenitor cells induce regulatory T cells and promote their suppressive phenotype via TGFβ and monocyte-dependent mechanisms

Abstract Dysregulation of the immune system can initiate chronic inflammatory responses that exacerbate disease pathology. Multipotent adult progenitor cells (MAPC cells), an adult adherent bone-marrow derived stromal cell, have been observed to promote the resolution of uncontrolled inflammatory re...

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Bibliographic Details
Main Authors: Alice Valentin-Torres, Cora Day, Jennifer M. Taggart, Nicholas Williams, Samantha R. Stubblefield, Valerie D. Roobrouck, Jelle Beyens, Anthony E. Ting
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93025-x

Internet

https://doi.org/10.1038/s41598-021-93025-x

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