Severity of Coronary Artery Involvement Correlates with Bone Turnover

• Main Authors: M Jafar Mahmoodi, H Saghafi, F Karimi, H Behzadi, B Larijani
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2008-12-01
• Series: Iranian Journal of Public Health
• Subjects: Bone turnover; Coronary artery disease; Cross laps; Osteocalcin; Osteoporosis
• Online Access: https://ijph.tums.ac.ir/index.php/ijph/article/view/2893
• ISSN: 2251-6085; 2251-6093

Background: To evaluate bone turnover in coronary artery disease patients by using biochemical markers of bone forma­tion and resorption. Methods: As a cross-sectional study, bone mineral density and serum osteocalcin and crosslaps were measured in 44 an­giographically documented coronary artery disease patients and 30 people with normal angiography invited to Endocrinol­ogy and Metabolism Research Center. Results: Bone mineral density of femur was significantly lower in patient with coronary artery disease (P= 0.04). Preva­lence of femur osteoporosis in patients with coronary artery disease was 43.2% whereas 14.8% of people with normal an­giography had femur osteoporosis (P= 0.01, OR= 4.37; CI95%, 1.29-14, 77).Serum level of osteocalcin and crosslaps ele­vated significantly with increasing severity of coronary artery disease. A significantly positive correlation was found be­tween coronary artery disease severity and serum level of osteocalcin (P= 0.008, r= 0.320). Crosslaps also showed similar cor­relation with number of diseased vessels (P= 0.02, r= 0.268). In multivariate analysis after adjustment of age, sex and BMI, severity of coronary artery disease was independently correlated with osteocalcin (P= 0.006) and crosslaps (P= 0.003). Conclusion: It seems that coronary artery disease and severity of atherosclerosis may be as a bone turnover predictor. Thus rec­ommendation of Bone density and turnover evaluation to patients with a coronary event may be valuable for earlier di­agnosis and prevention of osteoporosis and fracture.